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| 性 别： |
女 |
出生年月： |
1978-08-31 |
| 职 称： |
教授 |
工作单位： |
文理学院化学系 |
| 硕导（招生学科）： |
化学 |
博导（招生学科）： |
化学生物学/生物与医药 |
| 办公电话： |
0451-55190974 |
E-mail： |
gaoshuang@neau.edu.cn |
|
 |
| 课程编号 |
课程名称 |
课程类别 |
学时 |
| 20600005g |
普通化学 |
公共课 |
56 |
| 20600038j |
仪器分析 |
公共课 |
32 |
| 20600116x |
仪器分析 |
公共课 |
32 |
| 20600017g |
分析化学Ⅰ |
公共课 |
32 |
| 20610004g |
化学实验 |
公共课 |
96 |
| 20610038j |
仪器分析实验 |
公共课 |
32 |
| 20610039j |
仪器分析实验 |
专业课 |
64 |
| 主持科研项目概况 |
1、 国家自然科学基金，31801784，基于ALS除草剂的取代磺酰胺二氮（氧）杂二环类安全剂设计、合成及活性研究，2019/01-2021/12，24万元，结题，主持
2、黑龙江省博士后科研启动金，LBH-Q21076、农用超分子纳米纤维的创制与研究，2021/09-2024/08，6万元，在研，主持
3、 哈尔滨市科技创新人才基金，2017RAQXJ017、新型取代氧氮杂桥环类安全剂的设计、合成与构效研究，2017/09-2019/08，10万元，结题，主持
4、 黑龙江省博士后资助经费，LBH-Z16030，新型取代氧氮杂桥环类安全剂的设计、制备及修复机制研究，2017.01-2018.12 ，5万元，结题，主持
5、 黑龙江省自然科学基金面上项目，C2015013，取代氮氧杂环安全剂保护玉米免受除草剂药害的酶诱导作用研究，2014/01-2016/12，6万元，结题，主持。
6、 黑龙江省教育厅科学技术研究项目，12531027，安全剂保护玉米免受ALS除草剂药害的酶活性诱导及解毒机制研究，2013/01-2015/12，2万元，结题，主持。
7、 市科技创新人才项目，2010RFQYN108，新型除草剂安全剂二氯乙酰基噁唑烷的手性拆分与应用，2010/01-2012/12，2.7万元，结题，主持。 |
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| 项目获奖概况 |
1. 基于分子碎片重组设计的农用功能分子及其作用机制研究，2020.黑龙江省科学技术奖，二等奖（4）
2. 安全剂保护作物免受除草剂药害研究，2016. 08, 黑龙江省科学技术奖，二等奖（4）
3. 安全剂保护作物免受除草剂药害研究，2016.02, 年黑龙江省农业科技奖，一等奖（4） |
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| 代表性著作、论文 |
1. Gao, S; Liu, YY; Jiang, JY; Li, XM; Zhao, LX; Fu, Y; Ye, F. Encapsulation of thiabendazole in hydroxypropyl-beta-cyclodextrin nanofibers via polymer-free electrospinning and its characterization, Pest Management Science, 2020,76(9): 3264-3272, IF=4.845 (一区) （高被引论文）
2. Shuang Gao, Jingyu Jiang, Xiaoming Li, Fei Ye*, Ying Fu1* and Lixia Zhao. An Environmentally Safe Formulation with Enhanced Solubility and Fungicidal Activity: Self-assembly and Characterization of Difenoconazole-β-CD Inclusion Complex. Journal of Molecular Liquids, 2021, 327：114874 （SCI）IF=6.633 (二区) （高被引论文）
3. Shuang Gao, Yanyan Liu, Jingyu Jiang, Xiaoming Li, Fei Ye*, Ying Fu* and Lixia Zhao, Thiram/hydroxypropyl-beta-cyclodextrin inclusion complex electrospun nanofibers for a fast dissolving water-based drug delivery system. Colloids and Surfaces B: Biointerfaces, 2021, 201: 111625. https://doi.org/10.1016/j.colsurfb.2021.111625（SCI）IF=5.999 (二区)（高被引论文）
4. L. Lu, G. Shuang, Y. Liu, L. Yu-Long, L. Ping, Y. Fei, F. Ying, Cobalt (II) complex as a fluorescent sensing platform for the selective and sensitive detection of triketone HPPD inhibitors, Journal of Hazardous Materials, 2021,404: 124015（SCI）IF=10.588 (一区) （高被引论文）
5. Zhang, YY; Gao, S; Hoang, MT; Wang, ZW; Ma, X; Zhai, Y; Li, N; Zhao, LX; Fu, Y; Ye, F. Protective efficacy of phenoxyacetyl oxazolidine derivatives as safeners against nicosulfuron toxicity in maize, Pest Management Science ,2021, 77(1):177-183 DOI: 10.1002/ps.6005, IF= [4.845] (一区) （高被引论文）
6. Zhang Y-Y, Gao S, Liu Y-X, Wang C, Jiang W, Zhao L-X, et al., Design, Synthesis, and Biological Activity of Novel Diazabicyclo Derivatives as Safeners. Journal of Agricultural and Food Chemistry 2020, 68: 3403-3414 （SCI）IF=5.279 (一区) （高被引论文）
7. Shuang Gao , Weiwei Feng, Han Sun, Lei Zong, Xiaoming Li , Lixia Zhao , Fei Ye *, Ying Fu*, Fabrication and Characterization of Antifungal Hydroxypropyl-beta-Cyclodextrin/Pyrimethanil Inclusion Compound Nanofibers Based on Electrospinning Journal of Agricultural and Food Chemistry 2022, DOI10.1021/acs.jafc.2c01866（SCI）IF=5.895 (一区)
8. Shuang Gao , Xiaoming Li , Guang Yang , Weiwei Feng , Lei Zong , Lixia Zhao , Fei Ye *, Ying Fu Antibacterial perillaldehyde/hydroxypropyl-gamma-cyclodextrin inclusion complex electrospun polymer-free nanofiber: Improved water solubility, thermostability, and antioxidant activity. Industrial Crops & Products. 2022, 176: 114300（SCI）IF=6.449 (一区)
9. Hu, We, Gao, Shuang, Zhao, Li-Xia, Guo, Ke-Liang, Wang, Jia-Yu, Gao, Ying-Chao, Shao, Xin-Xin, Fu, Ying, Ye, Fei. Design, synthesis and biological activity of novel triketone-containing quinoxaline as HPPD inhibitor. Pest Management Science, 2022, 78（3）：938-946,https://doi.org/10.1002/ps.6703（SCI）IF=4.462 (一区)
10. Jia, Ling, Gao, Shuang, Zhang, Yuan-Yuan, Zhao, Li-Xia, Fu, Ying, Ye, Fei. Fragmenlt Recombination Design, Synthesis, and Safener Activity of Novel Ester-Substituted Pyrazole Derivatives. Journal of Agricultural and Food Chemistry 2021, 69, 8366−8379（SCI）IF=5.895 (一区)
11. Shuang Gao, Jingyu Jiang, Xiaoming Li, Fei Ye*, Ying Fu1* and Lixia Zhao.Electrospun Polymer-Free Nanofibers Incorporating Hydroxypropyl-beta-cyclodextrin/Difenoconazole via Supramolecular Assembly for Antifungal Activity. Journal of Agricultural and Food Chemistry 2021, 69, 5871−5881（SCI）IF=5.895 (一区)
12. Shuang Gao, Xiaoming Li, Jingyu Jiang, Lixia Zhao, Ying Fu, Fei Ye, Fabrication and Characterization of Thiophanate methylHydroxypropyl-beta-cyclodextrin Inclusion Complex Nanofibers by Electrospinning. Journal of Molecular Liquids, 2021, 335：116228 （SCI）IF=6.633 (二区)
13. Liu, Y; Gao, S; Yang, L ; Liu, YL; Liang, XM; Ye, F; Fu, Y. A Highly Selective Perylenediimide-Based Chemosensor: "Naked-Eye" Colorimetric and Fluorescent Turn-On Recognition for Al3+ . Frontiers in chemistry, 2020, 8: 702.（SCI）IF=5.221(二区)
14. Liu, YX; Gao, S ; Ye, T; Li, JZ; Ye, F; Fu, Y. Combined 3D-quantitative structure-activity relationships and topomer technology-based molecular design of human 4-hydroxyphenylpyruvate dioxygenase inhibitors, Future Medicinal Chemistry, 2020,12(9): 795-811.（SCI）IF=3.808 (二区)
15. Shuang Gao, Jingyu Jiang, Xiaoming Li, Yanyan Liu, Lixia Zhao, Ying Fu, Fei Ye. Enhanced physicochemical properties and herbicidal activity of an environment-friendly clathrate formed by β-cyclodextrin and herbicide cyanazine. Journal of Molecular Liquids, 2020,305, 112858. https://doi.org/10.1016/j.molliq.2020.112858（SCI）IF=6.165 (二区)
16. Gao, S.; Jiang, J.-Y.; Liu, Y.-Y.; Fu, Y.; Zhao, L.-X.; Li, C.-Y.; Ye, F. Enhanced Solubility, Stability, and Herbicidal Activity of the Herbicide Diuron by Complex Formation with β-Cyclodextrin. Polymers 2019, 11, 1396. （SCI）IF=3.164 (二区)
17. Shuang Gao , Yan-Yan Liu, Jing-Yu Jiang, Ying Fu, Li-Xia Zhao, Chun-Yan Li and Fei Ye. Protective Responses Induced by Chiral 3-Dichloroacetyl Oxazolidine Safeners in Maize (Zea mays L.) and the Detoxification Mechanism. Molecules 2019, 24, 3060; doi:10.3390/molecules24173060（SCI）IF=3.060 (三区)
18. Gao, S.; Bie, C.; Ji, Q.Y.; Ling, H.Y.; Li, C.Y.; Fu, Y.; Zhao, L.X.; Ye, F., Preparation and characterization of cyanazine–hydroxypropyl-beta-cyclodextrin inclusion complex. RSC Adv. 2019, 9, 26109-26115. （SCI）IF=3.049 (三区)
19. Gao, S.; Liu, Y. Y.; Jiang, J. Y.; Ji, Q. Y.; Fu, Y.; Zhao, L. X.; Li, C. Y.; Ye, F. Physicochemical properties and fungicidal activity of inclusion complexes of fungicide chlorothalonil with β-cyclodextrin and hydroxypropyl-β-cyclodextrin. Journal of Molecular Liquids, 2019, 293, 111513. doi:10.1016/j.molliq.2019.111513. （SCI）IF=4.564 (二区)
20. Shuang Gao, Chao Bie, Yanyan Liu, Tianyu Zhang, Ying Fu and Fei Ye*.Functional Supramolecular of Inclusion Complex of Herbicide Fluroxypyr with HPβCD. Polymers, 2018, 10, 1294（SCI）IF=3.364 (二区)
21. Gao Shuang, Wang Yuxin, Jiang Bin, Fu Ying*. Application of problem-based learning in instrumental analysis teaching at Northeast Agricultural University. Analytical and Bioanalytical Chemistry，2018, 410(16):3621-3627（SCI）IF=3.307
22. Fei Ye ; Hai-Feng Cao; Li-Na Wei; Chen Wang; Ying Fu; Chun-Yan Li; Shuang Gao*. Chiral 3-dichloroacetyl oxazolidines induced the activity of enzymes in maize for the detoxified herbicide, International Journal of Agriculture and Biology，2018,20,1027-1032（SCI）IF=0.869
23. Fei YE, Hai-Feng Cao, Xue-Song Chen, Meng ZHANG, Ying FU, Chun-Yan LI and Shuang GAO*.Effects of chiral 3-dichloroacetyl oxazolidine on glutathione S-transferase and antioxidant enzymes activity in maize treated with acetochlor，Tarim Bilimleri Dergisi-Journal of Agricultural Sciences. 2018,24(3): 422-429（SCI）IF=0.261
24. Gao, Shuang ; Bie, Chao; Chen, Xue-Song; Zhao, Li-Xia; Fu, Ying; Li,Chun-Yan; Ye, Fei *. Inducing Glutathione S-Transferase Expression and Activity using an Herbicide Safener against Metolachlor in Maize , International Journal of Agriculture and Biology, 2017, 19(6): 1357-1362.（SCI）IF=0.746
25. Gao, Shuang, Qu, Hai-Tao, Ye, Fei，Fu, Ying. Synthesis and Crystal Structure of N-Dichloroacetyl-3,4-dihydro-3-methyl-6-chloro-2H-1,4- benzoxazine; Journal of Chemistry; 2015, vol2015: 1-5.（SCI）IF=0.996
26. Shuang Gao, Ying Fu, Li-Xia Zhao, Zhi-Yong Xing，Fei Ye. Synthesis and Crystal Structure of Novel Chiral N-dichloroacetyl-2-substituted-5-methyl-1,3-oxazolidines; Heterocycles; 2012, 85(4):903-910.（SCI）IF=1.107
27. Shuang Gao, Li-Xia Zhao, Fei Ye, Ying Fu. 1-Dichloroacetyl-8a-methyl-1,2,3,4,6,7,8,8a-octahydro;Acta Cryst; 2012, E68(o1982) （SCI）IF=0.367
28. Fu, Ying, Kang, Jing-XinWang, Yun-Kai, Liu, Jing, Zhao, Li-Xia, Gao, Shuang,Ye, Fei;Design, Synthesis and Biological Activity of Novel Sulfonylurea Oxazolidines; Heterocycles; 2016, 92(4):740-750;（SCI）IF=1.107
29. Fei YE,Hai-Feng CAO, Ying FU, Li-Xia ZHAO, Shuang GAO. The safener effect of chiral derivatives of 3-dichloroacetyl oxazolidine against haloxyfop-P-methyl- induced toxicity in maize; Zemdirbyste-Agriculture;2016, 103(1):29-33;（SCI）IF=0.579
30. Li-xia Zhao, Hai-Tao Qu, Ying Fu, Shuang Gao, Fei Ye. Alleviation of injury from chlorimuron-ethyl in maize treated with safener 3-dichloroacetyl oxazolidine. Canadian Journal of Plant Science; 2015; 95: 1-7;（SCI） IF=0.727
31. Fei Ye, Fei Yang, Li-Xia Zhao, Shuang Gao, Ying Fu. Synthesis and crystal structure of novel N-acyl-2,3-dimethyl-3,4-2H-1,4- benzoxazine. Journal of Chemical Research. 2015, 39:357-359（SCI） IF=0.596
32. Fei Ye, Shi-Long Wu, Li-Xia Zhao, Hai-Tao Qu, Shuang Gao, and Ying Fu*. Synthesis and Safener Activity of Novel Substituted 4-Phenoxyacetyl-1,4-benzoxazines. Heterocycles. 2015, 91(6):1256-1268;（SCI）IF=1.107
33. Fei Ye, Shi-Long Wu, Shuang Gao, and Ying Fu*; Synthesis, Crystal Structure and Biological Activity of Novel Substituted N-Acetoxyacetyl-3-methyl-3,4-dihydro-2H-1,4-benzoxazine; Indian Journal of Heterocyclic Chemistry, 2015, 24(4): 481-486;（SCI）IF=0.207
34. Fei Ye, Fei Yang, Li-Xia Zhao, Shuang Gao and Ying Fu*; Synthesis and crystal structure of cis-N-acetoxyacetyl-2,3-dimethyl-3,4-dihydro-2H-1,4- benzoxazine; Indian Journal of Heterocyclic Chemistry, 2015, 25(2):126-132;（SCI）IF=0.207
35. Li-Xia Zhao，Ying Fu，Shuang Gao, Zhi-Yong Xing, Li-Na Wei, and Fei Ye*; Protective Responses Induced by 3-Dichloroacetyl Oxazolidine Safeners in Maize（Zeamays） International Journal of Agriculture and Biology; 2014,16(6):1204-1208;（SCI）IF=0.758
36. Fei Ye, Ying Li, Ying Fu,* Shuang Gao and Li-Xia Zhao; Microwave-Assisted Synthesis and Crystal Structure Of Novel 2-Dichloromethyl-1,3-Dioxolane Heterocycles; 2013,87(2): 407-415;（SCI）IF=1.107
37. 赵李霞,刘程国, 付颖, 高爽, 叶非*; 安全剂R-28725保护玉米免受氯磺 隆药害的作用研究; 植物保护; 2013, 39(1): 29-32;
38. Fei Ye, Cheng-Guo Liu, Xin-Ming Wang, Ying Fu*, Shuang Gao. A Convenient one-pot Synthesis of N-Dichloroacetyl-5-aryl-1,3-oxazolidines; Heterocyclic Communications; 2013; 19(3): 201-205;（SCI）IF=0.828
39. Fei Ye, Ying Li, Ying Fu*, Li-Xia Zhao, Shuang Gao, and Zhi-Yong Xing. Synthesis and crystal structure of 2-dichloromethyl-2-phenyl-1,3-dioxolane; Indian Journal of Heterocyclic Chemistry; 2013, 22(4): 349-352;（SCI）IF=0.207
40. Fei Ye, Shuang Gao, Ying Fu* , Xin-Ming Wang and Zhi-Yong Xing; Synthesis and biological studies of some novel 2-substituted-3-dichloroacetyl-1,3-oxazolidines. Indian Journal of Heterocyclic Chemistry; 2012, 21(3): 277-280;（SCI）IF=0.207
41. Li-Xia Zhao, Cheng-Guo Liu, Ying Fu, Zhi-Yong Xing, Fei Ye *, Shuang Gao; Induction of maize glutathione S-transferase by herbicide safener and their effect on enzyme activity against chlorsulfuron; Advanced Materials Research; 2012, 518-523:5480-5483;（EI）
42. Fei Ye, Ying Li, Ying Fu, Li-Xia Zhao and Shuang Gao; 1-(6-Bromo-3,4-dihydro -2H-1,4- benzoxazin-4-yl)-2,2-dichloroethanone, Acta Crystallographica Section E, 2012, E68, o2509;（SCI）IF=0.367
43. Ying Fu, Li-hua Qu, Shan-Shan Zhang, Fei Ye,* Li-xia Zhao, Shuang Gao, Zhi-Yong Xing; Simple and Efficient Synthesis of Novel N-Dichloroacetyl-3,4-dihydro-2H- 1,4-benzoxazines; Heterocyclic Communications; 2012; 18(3):143–146;（SCI）IF=0.828
44. Ying Fu, Hai-tao Li, Fei Ye*, Shuang Gao, Qing-Shan Zhao; Quantitative structure-activity relationship study on a novel series of N-dichloroacetyl oxazolidine herbicide Safeners; Indian Journal of Heterocyclic Chemistry; 2012, 21(4):375-380;（SCI）IF=0.207
45. Li-Xia Zhao, Ying Fu，Fei Ye,* Shuang Gao. A Mild and Highly Efficient Synthesis of Chiral N-DichloroacetylA-1,3-Oxazolidines; Journal of Heterocyclic Chemistry; 2012, 49(4):943-946;（SCI）IF=0.685
46. Ying Fu，Lei Yang，Fei Ye* and Shuang Gao; One-Pot Microwave-Assisted Synthesis of Novel Substituted N-Dichloroacetyl-4,5-dimethyl- 1,3-Oxazolidines; Journal of Heterocyclic Chemistry; 2012,49(5):1235-1238;（SCI）IF=0.685 .
47. Zhao, Li-Xia, Fu, Ying, Ye, Fei, Gao, Shuang; Synthesis and crystal structure of (R)-(-)-N-dichloroacetyl-3-ethyl-1-oxa-4-aza- spiro-4.5-decane; Heterocyclic Communications; 2011,17(1-2):53-55;（SCI）IF=0.828 |
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| 授权的专利等情况 |
1.高爽，李晓明，叶非，冯卫伟 一种紫苏醛纳米纤维及其制备方法和应用 ZL20211012996.3
2.付颖，叶非，高爽 一种含有喹喔啉结构的三酮类化合物、制备方法及其应用 ZL 201911193040.1
3.付颖，叶非，高爽 一种含肉桂酰基的三酮类化合物、制备方法及其应用 ZL201911191742.6
4.叶非，付颖，赵李霞，高爽 用于玉米生长的区域防治有害杂草的除草组合物及其用途 ZL201810750196.4 |
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| 其他获奖及荣誉称号 |
黑龙江省化学学会理事，黑龙江省自然科学基金评审专家，教育部学位中心学位论文评审专家，黑龙江省分析测试学会会员。 |
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